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In tumor cells, vitamin C often acts as a pro-oxidant due to high metal ion concentrations in the cytoplasm of the cell (such as Fe2+), which leads to oxidative stress due to reactions such as the Fenton reaction

For example, these approaches require generation of large-scale mutant populations or transgenic plants to screen for mutation in a gene of interest, which is a tedious and time consuming process

Archived from the original on 11 October 2007

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